Renoprotection by Helix B Surface Peptide in Puromycin Aminonucleoside-induced Nephrotic Syndrome
نویسندگان
چکیده
منابع مشابه
Calcitriol Prevents Cardiovascular Repercussions in Puromycin Aminonucleoside-Induced Nephrotic Syndrome
Puromycin aminonucleoside-induced nephrotic syndrome (PAN-NS) is characterized by cardiac remodeling and increased local inflammatory activity. Patients with NS and animal models of NS have vitamin D3 deficiency. The aim of the present study was to evaluate the influence of calcitriol on cardiac remodeling and local inflammatory state in PAN-NS rat model. Male Sprague-Dawley rats were injected ...
متن کاملChanges of atrial natriuretic Peptide system in rats with puromycin aminonucleoside-induced nephrotic syndrome.
Sodium retention is a hallmark of nephrotic syndrome. We investigated whether sodium retention is associated with changes of natriuretic peptide system at different stages (i.e., a sodium retaining stage and a compensatory stage) of nephrotic syndrome. At day 7 after PAN (puromycin aminonucleoside) injection, the urinary excretion of sodium was decreased, along with the development of ascites a...
متن کاملPlantago asiatica L. Ameliorates Puromycin Aminonucleoside-Induced Nephrotic Syndrome by Suppressing Inflammation and Apoptosis
OBJECTIVE Nephrotic syndrome, a kidney disease with a variety of causes, is mainly characterized by heavy proteinuria, hypoproteinemia, and ascites. This study was designed to evaluate the underlying mechanism of action of Plantago asiatica L. (PAL) in treating nephrotic syndrome induced by puromycin aminonucleoside. METHODS PAL has been used in Asia as a traditional medicine and dietary heal...
متن کاملEffect of Poria cocos on Puromycin Aminonucleoside-Induced Nephrotic Syndrome in Rats
Nephrotic syndrome is associated with altered renal handling of water and sodium and changes in the levels of aquaporins (AQPs) and epithelial Na channels (ENaCs). The dried sclerotia of Poria cocos Wolf (WPC) have been used for treating chronic edema and nephrosis. We evaluated the effects of WPC on puromycin aminonucleoside- (PAN-) induced renal functional derangement and altered renal AQP2 a...
متن کاملBlunted renal dopaminergic system activity in puromycin aminonucleoside-induced nephrotic syndrome.
BACKGROUND A primary tubular sodium handling abnormality has been implicated in the edema formation of nephrotic syndrome. Dopamine synthesized by renal proximal tubules behaves as an endogenous natriuretic hormone by activating D(1)-like receptors as a paracrine/autocrine substance. METHODS We examined the time courses of the urinary excretion of sodium, protein and dopamine in puromycin ami...
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ژورنال
عنوان ژورنال: Hong Kong Journal of Nephrology
سال: 2015
ISSN: 1561-5413
DOI: 10.1016/j.hkjn.2015.09.006